In these cases, certain atypical antipsychotic e.g.
Abilify (aripiprazole) and Risperdal can be helpful.
There are changes that occur long term in the number of catcher’s mitts produced; the postsynaptic neuron learns to accommodate the extra serotonin in the synapse by adjusting how many receptors there are. (If there were less serotonin in the synapse, the number of receptors would increase, called upregulation.) This up- and downregulation is the neurologic basis for tolerance to a drug.
If you keep on taking a drug that increases a neurotransmitter level, you will eventually develop fewer receptors for that transmitter.
Unless you change your perspective, you never get to see the truth.